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pentobarbital will decrease the level or impact of ondansetron by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check. No dosage adjustment for ondansetron is suggested for sufferers on these medications.pentobarbital will reduce the extent or effect of glecaprevir/pibrentasvir by impacting hepatic/intestinal enzyme CYP3A4 meta